epithelial mesothelioma - MY INFO a lining made of epithelial cells

he cells within a mesothelioma cancer tumor can vary from patient to patient. 


If your tumor is mainly composed of epithelioid cells, you may respond better to treatment and experience a more favorable outcome than patients with other cell types.
Mesothelioma develops in the mesothelium, a lining made of epithelial cells. When epithelial cells of the mesothelium turn cancerous, they alter in appearance and take on patterns called epithelioid, sarcomatoid or biphasic. Epithelioid mesothelioma, which is also called epithelial mesothelioma, is the most common type of the asbestos-related disease.
Although treatment does not typically differ from one cell type to the next, your type may dictate which clinical trials are available to you

.How Is It Diagnosed?

Epithelioid cells cannot be identified with diagnostic imaging scans. To determine which cell type is present, doctors need to perform a thoracoscopy or similar form of surgical biopsy. Biopsies offer doctors a way to examine the potentially cancerous cells under a high-powered microscope. During a biopsy, a tissue sample of the tumor is extracted for further evaluation of the cells it contains.
Epithelial mesothelioma distribution
Epithelioid mesothelioma accounts for the majority of cases.
One of the primary challenges of diagnosing epithelioid mesothelioma is distinguishing it from other types of cancer. Cancer in epithelial tissue could be a number of malignancies, which is why extensive testing is important. Epithelioid mesothelioma is often confused with adenocarcinoma, a common type of cancer that develops in the lungs, breasts and colon. Glandular mesothelioma, an epithelial cell subtype, may resemble adenocarcinoma of the lungs. It may be difficult to differentiate these two conditions.

Immunohistochemistry

Immunohistochemistry is a process that detects proteins called antibodies on the surface of cells. These proteins help classify a cancer’s cell type. Pathologists use immunohistochemistry to identify epithelioid mesothelioma cancer and differentiate it from adenocarcinoma. Immunohistochemistry is used less often to differentiate sarcomatoid mesothelioma from other sarcomatoid tumors.

What Is the Best Epithelioid Mesothelioma Treatment?

Because epithelioid mesothelioma cells respond best to treatment, a patient with this type may be considered for a more aggressive treatment plan. Epithelioid patients diagnosed before the cancer has spread throughout the chest often qualify for multimodal therapy, which attempts to kill cancer cells with multiple therapies. Multimodal therapy combines the most effective anticancer treatments for mesothelioma, including surgery, chemotherapy and radiation therapy.

In 1999, Dr. David Sugarbaker published impressive survival results among a group of pleural mesothelioma patients with malignant epithelial cells who had multimodal therapy that included an extrapleural pneumonectomy surgery, chemotherapy and radiation therapy. About 46 percent of patients who had epithelial cell type, no lymph node involvement and no remaining cancer cells after surgery lived at least five years. The typical five-year survival rate for mesothelioma cancer is around 10 percent.
Less than half of epithelioid patients qualify for aggressive surgery and multimodal therapy. And more than half are diagnosed too late to qualify for surgery regardless of cell type. When surgery isn’t an option, chemotherapy is considered standard of care and clinical trials are discussed.
Epithelioid patients have the widest variety of mesothelioma clinical trials to choose from. Most mesothelioma trials recruit epithelioid patients because their tumors respond best to 

Prognosis of Epitheioid Mesothelioma Is Good

The best prognosis is associated with epithelioid cells. The median survival time with epithelioid mesothelioma is about one year after diagnosis. Comparatively, patients with sarcomatoid mesothelioma live an average of six months.
The improved prognosis is around 200 days on average, but it could amount to years if the cancer is diagnosed in an early stage.
In 1996, a now well-known Swedish study examined tumor cell type as a prognostic factor in 85 cases of pleural mesothelioma. Patients with epithelioid mesothelioma survived about 200 days longer than patients with sarcomatoid or biphasic cell types. Those with tubulopapillary cells, a subtype of epithelial mesothelioma, lived 275 days longer than patients with other cell types.
Overall, epithelioid mesothelioma is associated with better response to treatment and longer survival. This cell type can open a window for patients to access aggressive treatment plans and innovative clinical trials.


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